Human papilloma virus in oral mucosa and its association with periodontal status of gynecologically infected women.

The aim of this study was to determine whether Human Papillomavirus was present in tongue and periodontium of periodontally healthy and diseased women who had genital lesions caused by the virus. Thirty non-menopausal women, systemically healthy and diagnosed with gynecological HPV lesions, were referred by the Gynecology Service Department of the University Maternal Neonatal Hospital of the City of Cordoba. Anamnesis, oral mucosa examination and periodontal clinical assessment were performed. Three brush samples were taken per patient: two from the same periodontal location (external epithelium of the gum and internal epithelium of the periodontal sulcus/pocket), and the third from the tongue. The 90 samples were submitted to Pap cytology and Polymerase Chain Reaction. The data were statistically analyzed by "Chi Square Test" (χ2) and "Kappa Index" (κ). High prevalence of HPV was found in the tongue (30%) and periodontal tissues (15%). High risk (HR) genotype -16 was detected with the highest percentage (67%), and genotypes -52 and -6 were also detected. Whenever HPV was present in periodontal location, it was also identified in the tongue of the same patients, of whom 88.89% reported that they practiced oral sex. Is worth noting the clinical finding of stomatologic lesions compatible with foliate papillitis in patients with positive intraoral HPV. High prevalence of HPV was found in the female population in Cordoba, with genotype -16 being detected at the highest percentage. No positive correlation was found between HPV and higher incidence and severity of periodontal lesions.

Human papilloma virus in oral mucosa and its association with periodontal status of gynecologically infected women

El objetivo del estudio fue identificar la presencia del virus Papiloma Humano en lengua y periodonto de mujeres sanas y enfermas periodontales con lesiones genitales del mismo. Se evaluarontreinta mujeres, no menopáusicas, de entre 18 y 50 años de edad, derivadas del Servicio de Ginecología del Hospital Universitario Materno Neonatal de la ciudad de Córdoba, sistémicamentesanas y con diagnóstico gineco lógico de lesiones por HPV. Se realizó, anamnesis, inspec ción de mucosas bucales, examen clínico periodontal y la toma de tres escobillados por paciente, dos de un mismo sitio periodontal (epitelio externo de encía y epitelio interno del surco/bolsa periodontal) y el otro de lengua. Las 90 muestras obtenidas fueron sometidas a estudios citológicos de Papanicolau y a estudios moleculares de amplificación de ácidos nucleicos por Reacción en Cadena de la Polimerasa. Los datos fueron agrupados y analizados por el “Test Chi Cuadrado” (χ2)y el “Índice de Kappa” (κ). Fue demostrada la alta prevalencia de la presencia del virus papiloma tanto en lengua (30 por ciento), como en tejidos periodontales (15 por ciento). El genotipo -16 de alto riesgo (HR) fue identificado en mayores porcentajes (67 por ciento) encontrando, también, el genotipo -52 y el -6. Siempre que el HPV estuvo presente en los sitios periodontales fue detectado, también, en la lengua de las mismas pacientes, de las cuáles el 88,89 por ciento practicabasexo oral. Se destaca el hallazgo clínico de lesiones estomatológicas compatibles con papilitis foliada en las pacientes HPVintrabucales positivas. Se señala en la población femenina de Córdoba, Argentina, la alta prevalencia de la presencia de HPV donde el genotipo -16 fue detectado en mayor porcentaje. En lamuestra analizada No fueron positivamente correlacionados lapresencia de HPV y la mayor incidencia y severidad de lesiones periodontales...

Human papilloma virus in oral mucosa and its association with periodontal status of gynecologically infected women. / Human papilloma virus in oral mucosa and its association with periodontal status of gynecologically infected women.

The aim of this study was to determine whether Human Papillomavirus was present in tongue and periodontium of periodontally healthy and diseased women who had genital lesions caused by the virus. Thirty non-menopausal women, systemically healthy and diagnosed with gynecological HPV lesions, were referred by the Gynecology Service Department of the University Maternal Neonatal Hospital of the City of Cordoba. Anamnesis, oral mucosa examination and periodontal clinical assessment were performed. Three brush samples were taken per patient: two from the same periodontal location (external epithelium of the gum and internal epithelium of the periodontal sulcus/pocket), and the third from the tongue. The 90 samples were submitted to Pap cytology and Polymerase Chain Reaction. The data were statistically analyzed by "Chi Square Test" (¤ç2) and "Kappa Index" (κ). High prevalence of HPV was found in the tongue (30

) and periodontal tissues (15

). High risk (HR) genotype -16 was detected with the highest percentage (67

), and genotypes -52 and -6 were also detected. Whenever HPV was present in periodontal location, it was also identified in the tongue of the same patients, of whom 88.89

reported that they practiced oral sex. Is worth noting the clinical finding of stomatologic lesions compatible with foliate papillitis in patients with positive intraoral HPV. High prevalence of HPV was found in the female population in Cordoba, with genotype -16 being detected at the highest percentage. No positive correlation was found between HPV and higher incidence and severity of periodontal lesions.